What's On

ViC Stem Cell Network - Monthly Seminar Series (August 2013)

04:00 PM - Tuesday 06 August, 2013

Join us on Tuesday 6 August 2013 to hear Dr Jose Polo from Monash University and the Australian Regenerative Medicine Insitute discuss his work unveiling the reprogramming process.

Time: 4pm – 5pm (refreshments served following seminar)

Venue: Level 5 Seminar room, Melbourne Brain Centre, The University of Melbourne

ABSTRACT: Unveiling the reprogramming process
The laboratory is interested in the transcriptional and epigenetic mechanisms that govern cell identity, in particular pluripotency and the reprogramming of somatic cells into induced pluripotent stem (iPS) cells. Being able to reprogram any specific mature cellular program into a pluripotent state and from there back into any other particular cellular program provides a unique tool to dissect the molecular and cellular events that permit the conversion of one cell type to another. Moreover, iPS cells and the reprogramming technology are of great interest in pharmaceutical and clinical settings, since the technology can be used to generate animal and cellular models for the study of various diseases as well in the future to provide specific patient tailor made cells for their use in cellular replacement therapies. However, despite being one of the major growing research fields very little is known about the epigenetic and transcriptome changes occurring during this process. Understanding the events leading to the generation of iPS cells is a necessary step to ultimately use iPS cell technology for therapeutic purposes. By using a broad array of approaches through the use of mouse models and a combination of different molecular, biochemical, cellular techniques and genome wide approaches, our lab aims to dissect the nature and dynamics of such events.

BIO: Jose Maria Polo was born in Buenos Aires, Argentina where he graduated from Buenos Aires University as a Biochemist. In 2002, Jose began his graduate studies at Albert Einstein College of Medicine, New York under the supervision of Dr. Ari Melnick where he worked on the transcriptional mechanism of the BCL6 repression complex in lymphomagenesis and B-cell maturation. In 2008 he obtained his PhD and moved to Boston to the laboratory of Dr. Konrad Hochedlinger at the Harvard Stem Cell Institute to work on reprogramming of adult cells into induced pluripotent stem (iPS) cells. In particular, his work focused in the acquisition of immortality and the existence of epigenetic memory during reprogramming. In June 2011 as a Larkins Fellow, Jose established his independent research group at Monash University.  In 2012, Jose was awarded a NHMRC Career Development Fellowship to continue his work in reprogramming and epigenetics. As of 2013, Jose holds appointments to the departments of Anatomy and Developmental Biology and to the Australian Regenerative Medicine Institute.